A temporal study on the histopathological, biochemical and molecular responses of CCl(4)-induced hepatotoxicity in Cyp2e1-null mice.

@article{Avasarala2006ATS,
  title={A temporal study on the histopathological, biochemical and molecular responses of CCl(4)-induced hepatotoxicity in Cyp2e1-null mice.},
  author={Sreedevi Avasarala and Lei Yang and Yan Sun and Alice Wan-Chi Leung and Wood-yee Chan and Wing-tai Cheung and Susanna Sau-Tuen Lee},
  journal={Toxicology},
  year={2006},
  volume={228 2-3},
  pages={310-22}
}
Previous study using Cyp2e1-null mice showed that Cyp2e1 is required in CCl(4)-induced liver injury at 24h, what remains unclear are the temporal changes in liver damage and the spectrum of genes involved in this process. We investigated the time-dependent liver changes that occurred at morphological, histopathological, biochemical and molecular levels in both Cyp2e1(+/+) and Cyp2e1(-/-) mice after treating with either corn oil or CCl(4) (1 ml/kg) for 2, 6, 12, 24 and 48 h. A pale orange… CONTINUE READING

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