A temporal study of axonal degeneration and glial scar formation following a standardized crush injury of the optic nerve in the adult rat.

@article{Ohlsson2004ATS,
  title={A temporal study of axonal degeneration and glial scar formation following a standardized crush injury of the optic nerve in the adult rat.},
  author={Marcus Ohlsson and Per Mattsson and Mikael Svensson},
  journal={Restorative neurology and neuroscience},
  year={2004},
  volume={22 1},
  pages={1-10}
}
PURPOSE In this methodological study, we describe a standardized optic nerve injury model in adult rats. The temporal pattern of the glial response is mapped in relation to axonal regeneration and degeneration. METHODS A standardized optic nerve crush injury was made in adult rats, using a fine pair of forceps with a preset pressure of 0.6 N during 10 seconds. RESULTS This crush injury resulted in a pronounced astroglial and microglial proliferation 2-7 dpi. Degenerative axons distal to the… CONTINUE READING

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