A template subtraction method for stimulus artifact removal in high-frequency deep brain stimulation.

@article{Hashimoto2002ATS,
  title={A template subtraction method for stimulus artifact removal in high-frequency deep brain stimulation.},
  author={Takao Hashimoto and Christopher M. Elder and Jerrold L. Vitek},
  journal={Journal of neuroscience methods},
  year={2002},
  volume={113 2},
  pages={181-6}
}
Deep brain stimulation (DBS) is a neurosurgical technique that has been widely applied for the treatment of tremor or motor symptoms associated with advanced Parkinson's disease. Large stimulus artifacts, however, have hampered investigations of physiological mechanisms underlying DBS effects using extracellular recording techniques. We have developed an off-line procedure for removing stimulus artifacts from recorded neuronal signals (monopolar) and applied this method of artifact subtraction… CONTINUE READING

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