A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel.

Abstract

INTRODUCTION Current regulatory guidelines for assessing the risk of QT prolongation include in vitro assays assessing drug effects on the human ether-à-go-go-related (hERG; also known as Kv11.1) channel expressed in cell lines. These assays are typically conducted at room temperature to promote the ease and stability of recording hERG currents. However… (More)
DOI: 10.1016/j.vascn.2016.05.005

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