A teleost polymeric Ig receptor exhibiting two Ig-like domains transports tetrameric IgM into the skin.

Abstract

The skin mucus IgM is an important molecule in the mucosal immune system of teleost skin. However, the transport mechanism associated with this molecule has yet to be clarified. In this study, we isolated a gene encoding a polymeric Ig receptor (pIgR) from a species of teleost fish, Takifugu rubripes (fugu). This gene is known to be an Ig transporter in the intestine of mammals. Our studies further demonstrated that fugu pIgR was expressed in the skin and that a fragment of pIgR bound to tetrameric IgM in the skin mucus. These results indicate that the skin pIgR transports tetrameric IgM into the skin mucus. The fugu pIgR exhibits a unique structure containing only two Ig-like domains corresponding to domain 1 and domain 4/5 of mammalian pIgR. This structure was sufficient for successful binding to tetrameric IgM. Teleost skin thus adopts the same Ig transport system as mammalian intestine via a unique pIgR.

7 Figures and Tables

01002002008200920102011201220132014201520162017
Citations per Year

542 Citations

Semantic Scholar estimates that this publication has 542 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Hamuro2007ATP, title={A teleost polymeric Ig receptor exhibiting two Ig-like domains transports tetrameric IgM into the skin.}, author={Koji Hamuro and Hiroaki Suetake and Nil Ratan Saha and Kiyoshi Kikuchi and Yuzuru Suzuki}, journal={Journal of immunology}, year={2007}, volume={178 9}, pages={5682-9} }