A technique to simultaneously visualize virus-specific CD8+ T cells and virus-infected cells in situ.

@article{Li2009ATT,
  title={A technique to simultaneously visualize virus-specific CD8+ T cells and virus-infected cells in situ.},
  author={Qingsheng Li and Pamela J Skinner and Lijie Duan and Ashley T Haase},
  journal={Journal of visualized experiments : JoVE},
  year={2009},
  volume={30}
}
The numbers and locations of virus-specific CD8+ T cells relative to the numbers and locations of their infected cell targets is thought to be critical in determining outcomes that range from clearance to chronic persistent infections. We describe here a method for assessing the spatial and quantitative relationships between immune effector (E) virus-specific CD8+ T cells and infected targets (T) that combines in situ tetramer (IST) staining to detect virus-specific CD8+ T cells and in situ… CONTINUE READING

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