A technique to measure cold adaptation in freely behaving mice.

@article{Brenner2014ATT,
  title={A technique to measure cold adaptation in freely behaving mice.},
  author={Daniel S. Brenner and Sherri K. Vogt and Robert W Gereau},
  journal={Journal of neuroscience methods},
  year={2014},
  volume={236},
  pages={86-91}
}
BACKGROUND Adaptation to environmental temperature is essential for survival in seasonal areas. The mechanisms of adaptation have been studied in vitro, but it has not been quantified in vivo. NEW METHOD The extended Cold Plantar Assay (eCPA) cools the entire testing environment. Once the desired environmental temperature has been reached, a separate focal cold stimulus is applied to the hindpaw and the latency to withdrawal is recorded as a proxy for cold sensitivity. RESULTS Using this… CONTINUE READING