A technique to immobilize bioactive proteins, including bone morphogenetic protein-4 (BMP-4), on titanium alloy.

@article{Puleo2002ATT,
  title={A technique to immobilize bioactive proteins, including bone morphogenetic protein-4 (BMP-4), on titanium alloy.},
  author={David A. Puleo and Rudolf Kissling and Min Shyan Sheu},
  journal={Biomaterials},
  year={2002},
  volume={23 9},
  pages={2079-87}
}
Immobilization of biomolecules on surfaces enables both localization and retention of molecules at the cell-biomaterial interface. Since metallic biomaterials used for orthopedic and dental implants possess a paucity of reactive functional groups, biomolecular modification of these materials is challenging. In the present work, we investigated the use of a plasma surface modification strategy to enable immobilization of bioactive molecules on a "bioinert" metal. Conditions during plasma… CONTINUE READING

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