A technique for the quantification of human and non-human mammalian mitochondrial DNA copy number in forensic and other mixtures.

@article{Tobe2008ATF,
  title={A technique for the quantification of human and non-human mammalian mitochondrial DNA copy number in forensic and other mixtures.},
  author={Shanan S. Tobe and Adrian M. T. Linacre},
  journal={Forensic science international. Genetics},
  year={2008},
  volume={2 4},
  pages={249-56}
}
The number of mitochondria per cell varies by cell type and the number of mitochondrial DNA (mtDNA) genomes varies per mitochondrion. Biological samples from unknown species are encountered frequently in forensic science investigations and are often contaminated with human mtDNA making analysis difficult. Currently, no techniques to quantify non-human mtDNA are available. We report on a method to accurately quantify, sensitive to 100 copies (1.7fg), mtDNA from human and non-human sources when… CONTINUE READING
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