A technique for the chronic study of the hepatic uptake and excretion of substances in the conscious pig.

Abstract

The pig is an ideal animal for studies of hepatic metabolism and the handling of drugs by the liver because of the many similarities in liver function to that in man. In this report we describe for the first time, in this animal, methods for the chronic implantation of sampling catheters in the major hepatic vessels and for the construction of an external… (More)

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