A technique for automatic/interactive assessment of the proliferating fraction of neoplastic cells in solid tumors. A methodological study on the Ki-67 immunoreactive cells in human mammary carcinomas, including a comparison with the results of conventional S-phase fraction assessments by means of DNA cytometry.

@article{Parrado1996ATF,
  title={A technique for automatic/interactive assessment of the proliferating fraction of neoplastic cells in solid tumors. A methodological study on the Ki-67 immunoreactive cells in human mammary carcinomas, including a comparison with the results of conventional S-phase fraction assessments by means of DNA cytometry.},
  author={Concepci{\'o}n Parrado and Ursula Gerda Falkmer and Ander H{\"o}{\"o}g and Sture Falkmer and Oliver Ahrens and Ferran Rius and Lars Grimelius},
  journal={General & diagnostic pathology},
  year={1996},
  volume={141 3-4},
  pages={215-27}
}
Based on a computerized microscopy technique, a method has been devised which allows the practising pathologist to easily and rapidly assess quantitatively the relative number of actively proliferating neoplastic parenchymal cells in a tumor nodule. Our method has been tested on a series of 20 conventionally formalin-fixed and paraffin-embedded female… CONTINUE READING