A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei.

@article{Leonhardt1992ATS,
  title={A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei.},
  author={Heinrich Leonhardt and Andrea W. Page and Heinz Ulrich G. Weier and Timothy H Bestor},
  journal={Cell},
  year={1992},
  volume={71 5},
  pages={865-73}
}
Tissue-specific patterns of methylated deoxycytidine residues in the mammalian genome are preserved by postreplicative methylation of newly synthesized DNA. DNA methyltransferase (MTase) is here shown to associate with replication foci during S phase but to display a diffuse nucleoplasmic distribution in non-S phase cells. Analysis of DNA MTase-beta-galactosidase fusion proteins has shown that association with replication foci is mediated by a novel targeting sequence located near the N… CONTINUE READING
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