A targeted spatial-temporal proteomics approach implicates multiple cellular trafficking pathways in human cytomegalovirus virion maturation.

@article{Moorman2010ATS,
  title={A targeted spatial-temporal proteomics approach implicates multiple cellular trafficking pathways in human cytomegalovirus virion maturation.},
  author={Nathaniel J. Moorman and Ronit Sharon-Friling and Thomas E. Shenk and Ileana M. Cristea},
  journal={Molecular & cellular proteomics : MCP},
  year={2010},
  volume={9 5},
  pages={
          851-60
        }
}
The assembly of infectious virus particles is a complex event. For human cytomegalovirus (HCMV) this process requires the coordinated expression and localization of at least 60 viral proteins that comprise the infectious virion. To gain insight into the mechanisms controlling this process, we identified protein binding partners for two viral proteins, pUL99 (also termed pp28) and pUL32 (pp150), which are essential for HCMV virion assembly. We utilized HCMV strains expressing pUL99 or pUL32… CONTINUE READING

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