A targeted quantitative proteomics strategy for global kinome profiling of cancer cells and tissues.

@article{Xiao2014ATQ,
  title={A targeted quantitative proteomics strategy for global kinome profiling of cancer cells and tissues.},
  author={Yongsheng Xiao and Lei Guo and Yinsheng Wang},
  journal={Molecular & cellular proteomics : MCP},
  year={2014},
  volume={13 4},
  pages={1065-75}
}
Kinases are among the most intensively pursued enzyme superfamilies as targets for anti-cancer drugs. Large data sets on inhibitor potency and selectivity for more than 400 human kinases became available recently, offering the opportunity to design rationally novel kinase-based anti-cancer therapies. However, the expression levels and activities of kinases are highly heterogeneous among different types of cancer and even among different stages of the same cancer. The lack of effective strategy… CONTINUE READING
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