A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung.

@article{Moens1992ATM,
  title={A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung.},
  author={Cecilia B Moens and Anna B. Auerbach and Ronald A. Conlon and Alexandra L. Joyner and Janet Rossant},
  journal={Genes & development},
  year={1992},
  volume={6 5},
  pages={691-704}
}
The N-myc proto-oncogene encodes a putative transcription factor that has been postulated to be involved in the control of differentiation in a number of lineages at various stages during mammalian embryogenesis. We have generated a leaky mutation in N-myc by gene targeting in embryonic stem cells. In this allele, the neo(r) gene was inserted into the first intron of N-myc, in such a way that alternative splicing around this insertion could result in the generation of a normal N-myc transcript… CONTINUE READING