A targeted mutation in the IL-4Ralpha gene protects mice against autoimmune diabetes.

@article{Radu2000ATM,
  title={A targeted mutation in the IL-4Ralpha gene protects mice against autoimmune diabetes.},
  author={Dorel Lucian Radu and Nancy Noben-Trauth and Jane Hu-Li and W. Jack Christie Edwin J. Crossman Peter J. Doherty A Paul and Constantin A. Bona},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 23},
  pages={12700-4}
}
Autoimmune insulin-dependent diabetes mellitus (IDDM) occurs spontaneously in mice-bearing transgenes encoding the influenza hemagglutinin under the control of the rat insulin promoter and a T cell receptor specific for an hemagglutinin peptide associated with I-E(d). Such "double transgenic" mice expressing wild-type or targeted IL-4Ralpha genes were examined for the onset of IDDM. Eight of 11 mice homozygous for wild-type IL-4Ralpha were hyperglycemic by 8 weeks of age, whereas only 1 of 16… CONTINUE READING

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Fundamentals of Biostatistics (Wadsworth

  • B. Rosner
  • Belmont, CA),
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