A targeted multienzyme mechanism for selective microtubule polyglutamylation.

@article{Dijk2007ATM,
  title={A targeted multienzyme mechanism for selective microtubule polyglutamylation.},
  author={J. Van Dijk and Krzysztof Rogowski and J. Miro and Benjamin Lacroix and B. Edd{\'e} and C. Janke},
  journal={Molecular cell},
  year={2007},
  volume={26 3},
  pages={
          437-48
        }
}
Polyglutamylases are enzymes that form polyglutamate side chains of variable lengths on proteins. Polyglutamylation of tubulin is believed to regulate interactions of microtubules (MTs) with MT-associated proteins and molecular motors. Subpopulations of MTs are differentially polyglutamylated, yet only one modifying enzyme has been discovered in mammals. In an attempt to better understand the heterogeneous appearance of tubulin polyglutamylation, we searched for additional enzymes and report… Expand
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