A targeted gene knockout in Drosophila.

  title={A targeted gene knockout in Drosophila.},
  author={Yikang S Rong and Kent G. Golic},
  volume={157 3},
We previously described a method for targeted homologous recombination at the yellow gene of Drosophila melanogaster. Because only a single gene was targeted, further work was required to show whether the method could be extended to become generally useful for gene modification in Drosophila. We have now used this method to produce a knockout of the autosomal pugilist gene by homologous recombination between the endogenous locus and a 2.5-kb DNA fragment. This was accomplished solely by… CONTINUE READING


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