A tale of two termini: a functional interaction between the termini of an mRNA is a prerequisite for efficient translation initiation.

@article{Gallie1998ATO,
  title={A tale of two termini: a functional interaction between the termini of an mRNA is a prerequisite for efficient translation initiation.},
  author={Daniel R Gallie},
  journal={Gene},
  year={1998},
  volume={216 1},
  pages={1-11}
}
A quarter of century following the prediction that mRNAs are translated in a circular form, recent biochemical and genetic evidence has accumulated to support the idea that communication between the termini of an mRNA is necessary to promote translation initiation. The poly(A)-binding protein (PABP) interacts with the cap-associated eukaryotic initiation factor (eIF) 4G (in yeast and plants) and eIF4B (in plants), a functional consequence of which is to increase the affinity of PABP for poly(A… CONTINUE READING