A tale of two subunits: how the neomorphic R132H IDH1 mutation enhances production of αHG.

@article{Pietrak2011ATO,
  title={A tale of two subunits: how the neomorphic R132H IDH1 mutation enhances production of αHG.},
  author={Beth Pietrak and Huizhen Zhao and Hongwei Qi and Chad Quinn and Enoch N. Gao and J Gregory Boyer and Nestor O. Concha and Kristin A Brown and Chaya Duraiswami and Richard Wooster and Sharon Sweitzer and Benjamin K Schwartz},
  journal={Biochemistry},
  year={2011},
  volume={50 21},
  pages={4804-12}
}
Heterozygously expressed single-point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2, respectively) render these dimeric enzymes capable of producing the novel metabolite α-hydroxyglutarate (αHG). Accumulation of αHG is used as a biomarker for a number of cancer types, helping to identify tumors with similar IDH mutations. With IDH1, it has been shown that one role of the mutation is to increase the rate of conversion from αKG to αHG. To improve our understanding of the function… CONTINUE READING