A tale of two domains - a structural perspective of the pseudokinase, MLKL.

@article{Czabotar2015ATO,
  title={A tale of two domains - a structural perspective of the pseudokinase, MLKL.},
  author={Peter E. Czabotar and James M Murphy},
  journal={The FEBS journal},
  year={2015},
  volume={282 22},
  pages={4268-78}
}
Recently, the programmed necrosis or 'necroptosis' cell death pathway has attracted much interest because of its implication in multiple pathologies, including inflammatory diseases and the cell death arising from ischaemia reperfusion injuries. Pharmacologically, necroptosis is an attractive target because, unlike the counterpart pathway, apoptosis, it is dispensable for mammalian development. In particular, the most terminal-known obligate effector in the necroptosis pathway, the pseudokinase… CONTINUE READING
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