A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol.

@article{Russo2006ATO,
  title={A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol.},
  author={Ethan B. Russo and Geoffrey William Guy},
  journal={Medical hypotheses},
  year={2006},
  volume={66 2},
  pages={
          234-46
        }
}
  • Ethan B. Russo, Geoffrey William Guy
  • Published 2006
  • Medicine
  • Medical hypotheses
  • This study examines the current knowledge of physiological and clinical effects of tetrahydrocannabinol (THC) and cannabidiol (CBD) and presents a rationale for their combination in pharmaceutical preparations. Cannabinoid and vanilloid receptor effects as well as non-receptor mechanisms are explored, such as the capability of THC and CBD to act as anti-inflammatory substances independent of cyclo-oxygenase (COX) inhibition. CBD is demonstrated to antagonise some undesirable effects of THC… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 342 CITATIONS, ESTIMATED 52% COVERAGE

    Cannabinoids in the management of difficult to treat pain

    Cannabinoids:their role in pain and palliation.

    [Therapeutical use of the cannabinoids in psychiatry].

    VIEW 2 EXCERPTS
    CITES BACKGROUND

    FILTER CITATIONS BY YEAR

    2006
    2020

    CITATION STATISTICS

    • 28 Highly Influenced Citations

    • Averaged 33 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 112 REFERENCES

    Neuroprotective antioxidants from marijuana.

    VIEW 2 EXCERPTS

    The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.

    VIEW 2 EXCERPTS

    Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines

    Hypnotic and antiepileptic effects of cannabidiol.

    VIEW 4 EXCERPTS
    HIGHLY INFLUENTIAL