A t(1;19) chromosome translocation in three cases of human malignant melanoma.

@article{Parmiter1986ATC,
  title={A t(1;19) chromosome translocation in three cases of human malignant melanoma.},
  author={Annette H. Parmiter and Geni Balaban and Meenhard Herlyn and Wallace H. Clark and Peter C. Nowell},
  journal={Cancer research},
  year={1986},
  volume={46 3},
  pages={1526-9}
}
Abnormalities of chromosome 1, including trisomy for all or a portion of the long arm, have been frequently reported in many cancers. Anomalies of chromosome 19 are far less common, although a t(1;19)(q23;p13) translocation has been reported in association with pre-B-cell leukemia. We have observed a t(1;19)(q12;p13) translocation in three cases of advanced melanoma, with the translocation chromosome representing an extra dose of 1q in each instance. The breakpoint on 1q was within the… CONTINUE READING

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