A systems-level approach to parental genomic imprinting: the imprinted gene network includes extracellular matrix genes and regulates cell cycle exit and differentiation.

@article{Adhami2015ASA,
  title={A systems-level approach to parental genomic imprinting: the imprinted gene network includes extracellular matrix genes and regulates cell cycle exit and differentiation.},
  author={Hala Al Adhami and Brendan Evano and Anne Le Digarcher and Charlotte Gueydan and Emeric Dubois and Hugues Parrinello and Christelle Dantec and Tristan Bouschet and Annie Varrault and Laurent Journot},
  journal={Genome research},
  year={2015},
  volume={25 3},
  pages={353-67}
}
Genomic imprinting is an epigenetic mechanism that restrains the expression of ∼ 100 eutherian genes in a parent-of-origin-specific manner. The reason for this selective targeting of genes with seemingly disparate molecular functions is unclear. In the present work, we show that imprinted genes are coexpressed in a network that is regulated at the transition from proliferation to quiescence and differentiation during fibroblast cell cycle withdrawal, adipogenesis in vitro, and muscle… CONTINUE READING
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