A systems biology framework identifies molecular underpinnings of coronary heart disease.

@article{Huan2013ASB,
  title={A systems biology framework identifies molecular underpinnings of coronary heart disease.},
  author={Tianxiao Huan and Bin Zhang and Zhi Wang and Roby Joehanes and Jun Zhu and Andrew D. Johnson and Saixia Ying and Peter J. Munson and Nalini Raghavachari and Richard J Wang and Poching Liu and Paul Courchesne and S. -Y. Hwang and Themistocles L. Assimes and Ruth Mcpherson and Nilesh J. Samani and Heribert Schunkert and Qingying Meng and Christine Suver and Christopher J. O'Donnell and Jonathan M.J. Derry and Xia Yang and Daniel L{\'e}vy},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2013},
  volume={33 6},
  pages={1427-34}
}
OBJECTIVE Genetic approaches have identified numerous loci associated with coronary heart disease (CHD). The molecular mechanisms underlying CHD gene-disease associations, however, remain unclear. We hypothesized that genetic variants with both strong and subtle effects drive gene subnetworks that in turn affect CHD. APPROACH AND RESULTS We surveyed CHD-associated molecular interactions by constructing coexpression networks using whole blood gene expression profiles from 188 CHD cases and 188… CONTINUE READING