A systems biology approach to analyse amplification in the JAK2-STAT5 signalling pathway

@article{Vera2008ASB,
  title={A systems biology approach to analyse amplification in the JAK2-STAT5 signalling pathway},
  author={Julio Vera and Julie Bachmann and Andrea C. Pfeifer and Verena Becker and Jose A. Hormiga and N{\'e}stor Torres Darias and Jens Timmer and Ursula Klingm{\"u}ller and Olaf Wolkenhauer},
  journal={BMC Systems Biology},
  year={2008},
  volume={2},
  pages={38 - 38}
}
The amplification of signals, defined as an increase in the intensity of a signal through networks of intracellular reactions, is considered one of the essential properties in many cell signalling pathways. Despite of the apparent importance of signal amplification, there have been few attempts to formalise this concept. In this work we investigate the amplification and responsiveness of the JAK2-STAT5 pathway using a kinetic model. The recruitment of EpoR to the plasma membrane, activation by… CONTINUE READING
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