A systems biology approach identifies the biochemical mechanisms regulating monoterpenoid essential oil composition in peppermint

@article{RosEstepa2008ASB,
  title={A systems biology approach identifies the biochemical mechanisms regulating monoterpenoid essential oil composition in peppermint},
  author={Rigoberto R{\'i}os-Estepa and Glenn W. Turner and James M. Lee and Rodney B. Croteau and Bernd Markus Lange},
  journal={Proceedings of the National Academy of Sciences},
  year={2008},
  volume={105},
  pages={2818 - 2823}
}
The integration of mathematical modeling and experimental testing is emerging as a powerful approach for improving our understanding of the regulation of metabolic pathways. In this study, we report on the development of a kinetic mathematical model that accurately simulates the developmental patterns of monoterpenoid essential oil accumulation in peppermint (Mentha × piperita). This model was then used to evaluate the biochemical processes underlying experimentally determined changes in the… 
Mathematical Modeling-Guided Evaluation of Biochemical, Developmental, Environmental, and Genotypic Determinants of Essential Oil Composition and Yield in Peppermint Leaves1[W][OA]
TLDR
Simulated and measured essential oil profiles were in very good agreement, indicating that modeling is a valuable tool for guiding metabolic engineering efforts aimed at improving essential oil quality and quantity.
Kinetic modeling of plant metabolism and its predictive power: peppermint essential oil biosynthesis as an example.
TLDR
This article describes a kinetic mathematical model of peppermint essential oil biosynthesis, a pathway that has been studied extensively for more than two decades and provides step-by-step instructions on how to run simulations of dynamic changes in pathway metabolites concentrations.
Improving peppermint essential oil yield and composition by metabolic engineering
TLDR
The utility of metabolic engineering for the sustainable agricultural production of high quality essential oils at a competitive cost is illustrated.
Bioenergetics of Monoterpenoid Essential Oil Biosynthesis in Nonphotosynthetic Glandular Trichomes1[OPEN]
TLDR
This study provides the first evidence of how bioenergetic processes determine flux through monoterpene biosynthesis in GTs, and reports that GTs with high flux toward monoterpenes express, at very high levels, genes coding for a unique pair of ferred toxin and ferredoxin-NADP+ reductase isoforms.
Transcriptome Analysis of Light-Regulated Monoterpenes Biosynthesis in Leaves of Mentha canadensis L.
TLDR
A series of responsive transcription factors (TFs) were identified and could be used in metabolic engineering as an effective strategy for increasing essential oil yields and the genes involved in the light signal transduction pathway were analyzed.
Recent advances and challenges in trichome research and essential oil biosynthesis in Mentha arvensis L
TLDR
Genetic investigations on elucidation of essential oil biosynthetic pathway and the respective enzymes would provide a focused insight, opening new possibilities for genetic engineering and development of better varieties of Mentha with improved agro-economic traits.
The application of synthetic biology to elucidation of plant mono-, sesqui-, and diterpenoid metabolism.
TLDR
This review describes the emerging use of synthetic biology to recombinantly reconstitute plant terpenoid biosynthetic pathways in heterologous host organisms as a functional discovery tool, with a particular focus on incorporation of the historically problematic cytochrome P450 mono-oxygenases.
The mevalonate pathway contributes to monoterpene production in peppermint
TLDR
The potential of 13C-MFA to ascertain previously unquantified metabolic routes of the trichomes is revealed and thus advancing insights on metabolic engineering of this organ are revealed.
Relative expression of genes of menthol biosynthesis pathway in peppermint (Mentha piperita L.) after chitosan, gibberellic acid and methyl jasmonate treatments
Menthol as an important component of monoterpenes essential oil in peppermint (Mentha piperita L.) is widely applied for medical and industrial uses. In this study, the effect of exogenous
Assessing the Biosynthetic Capabilities of Secretory Glands in Citrus Peel1[W][OA]
TLDR
Morphometric analyses demonstrated that secretory cavities are formed early during fruit development, whereas the expansion of cavities, and thus oil accumulation, correlates with later stages of fruit expansion.
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