A systems biology approach for the investigation of the heparin/heparan sulfate interactome.

@article{Ori2011ASB,
  title={A systems biology approach for the investigation of the heparin/heparan sulfate interactome.},
  author={Alessandro Ori and M. C. Wilkinson and David G Fernig},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 22},
  pages={19892-904}
}
A large body of evidence supports the involvement of heparan sulfate (HS) proteoglycans in physiological processes such as development and diseases including cancer and neurodegenerative disorders. The role of HS emerges from its ability to interact and regulate the activity of a vast number of extracellular proteins including growth factors and extracellular matrix components. A global view on how protein-HS interactions influence the extracellular proteome and, consequently, cell function is… CONTINUE READING

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hp://w w w .jb.org/ D

  • J. Gough, K. Karplus, R. Hughey, C. Chothia
  • J. Mol. Biol. 313,
  • 2001

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