A systems biology approach for pathway level analysis.

@article{Draghici2007ASB,
  title={A systems biology approach for pathway level analysis.},
  author={Sorin Draghici and Purvesh Khatri and Adi L. Tarca and Kashyap Amin and Arina Done and Calin Voichita and Constantin Georgescu and Roberto Romero},
  journal={Genome research},
  year={2007},
  volume={17 10},
  pages={
          1537-45
        }
}
A common challenge in the analysis of genomics data is trying to understand the underlying phenomenon in the context of all complex interactions taking place on various signaling pathways. A statistical approach using various models is universally used to identify the most relevant pathways in a given experiment. Here, we show that the existing pathway analysis methods fail to take into consideration important biological aspects and may provide incorrect results in certain situations. By using… CONTINUE READING

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