A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase

@article{Hinkley2011ASA,
  title={A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase},
  author={Trevor Hinkley and Jo{\~a}o Z R Martins and Colombe Chappey and Mojgan Haddad and Eric Stawiski and Jeannette M. Whitcomb and Christos J. Petropoulos and Sebastian Bonhoeffer},
  journal={Nature Genetics},
  year={2011},
  volume={43},
  pages={487-489}
}
The development of a quantitative understanding of viral evolution and the fitness landscape in HIV-1 drug resistance is a formidable challenge given the large number of available drugs and drug resistance mutations. We analyzed a dataset measuring the in vitro fitness of 70,081 virus samples isolated from HIV-1 subtype B infected individuals undergoing routine drug resistance testing. We assayed virus samples for in vitro replicative capacity in the absence of drugs as well as in the presence… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 32 references

An introduction into support vector machines

N. Christianini, J. Shawe-Taylor
2000
View 5 Excerpts
Highly Influenced

Generalized Linear Models

View 3 Excerpts
Highly Influenced

Principal component analysis of general patterns of HIV - 1 replicative fitness in different drug environments

J. Z. Martins
Epidemics • 2010

Update of the Drug Resistance Mutations in HIV-1.

Topics in HIV medicine : a publication of the International AIDS Society, USA • 2008

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