A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase

  title={A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase},
  author={Trevor Hinkley and Jo{\~a}o Z R Martins and Colombe Chappey and Mojgan Haddad and Eric Stawiski and Jeannette M. Whitcomb and Christos J. Petropoulos and Sebastian Bonhoeffer},
  journal={Nature Genetics},
The development of a quantitative understanding of viral evolution and the fitness landscape in HIV-1 drug resistance is a formidable challenge given the large number of available drugs and drug resistance mutations. We analyzed a dataset measuring the in vitro fitness of 70,081 virus samples isolated from HIV-1 subtype B infected individuals undergoing routine drug resistance testing. We assayed virus samples for in vitro replicative capacity in the absence of drugs as well as in the presence… CONTINUE READING
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Publications referenced by this paper.
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N. Christianini, J. Shawe-Taylor
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Generalized Linear Models

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Epidemics • 2010

Update of the Drug Resistance Mutations in HIV-1.

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