A systemic complete response of metastatic melanoma to local radiation and immunotherapy.

@article{Hiniker2012ASC,
  title={A systemic complete response of metastatic melanoma to local radiation and immunotherapy.},
  author={Susan M. Hiniker and Daniel S. Chen and Sunil Reddy and Daniel Tandel Chang and Jennifer C Jones and Joseph A. Mollick and Susan M. Swetter and Susan J. Knox},
  journal={Translational oncology},
  year={2012},
  volume={5 6},
  pages={404-7}
}
BACKGROUND Melanoma is a relatively immunogenic tumor, in which infiltration of melanoma cells by T lymphocytes is associated with a better clinical prognosis. We hypothesized that radiation-induced cell death may provide additional stimulation of an anti-tumor immune response in the setting of anti-CTLA-4 treatment. METHODS In a pilot melanoma patient, we prospectively tested this hypothesis. We treated the patient with two cycles of ipilimumab, followed by stereotactic ablative radiotherapy… CONTINUE READING