A systematic review on the role of fish oil for the treatment of cachexia in advanced cancer: An EPCRC cachexia guidelines project

@article{Ries2012ASR,
  title={A systematic review on the role of fish oil for the treatment of cachexia in advanced cancer: An EPCRC cachexia guidelines project},
  author={Anke Ries and Peter Trottenberg and Frank Elsner and Stephanie Stiel and Dagny Faksv{\aa}g Haugen and Stein Kaasa and Lukas Radbruch},
  journal={Palliative Medicine},
  year={2012},
  volume={26},
  pages={294 - 304}
}
Background: The European Palliative Care Research Collaboration is developing clinical guidelines on cachexia in patients with advanced cancer. A systematic review on the use of fish oil/omega-3-fatty acids (n-3-FA)/eicosapentaenoic acids (EPA) in advanced cancer patients suffering from cancer cachexia was performed as part of the guideline development. Methods: The systematic literature search in Medline on the use of fish oil/n-3-FA/EPA identified 244 papers, with 38 publications included in… Expand
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  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
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TLDR
Administration of n-3 FA (EPA and DHA) in doses of at least 1.5 g/day for a prolonged period of time to patients with advanced cancer is associated with an improvement in clinical, biological and QoL parameters. Expand
Anorexia-cachexia syndrome: a systematic review of the role of dietary polyunsaturated Fatty acids in the management of symptoms, survival, and quality of life.
TLDR
None of the trials found a clinically or statistically significant difference in outcome measures reviewed, and EPA and DHA alone have not shown significant clinical effect in altering weight, lean muscle mass, survival, or QoL in patients with ACS associated with cancer. Expand
Eicosapentaenoic acid (EPA, an omega-3 fatty acid from fish oils) for the treatment of cancer cachexia.
TLDR
Comparisons of EPA combined with aprotein energy supplementation versus a protein energy supplementation (without EPA) in the presence of an appetite stimulant provided no evidence that EPA improves symptoms associated with the cachexia syndrome often seen in patients with advanced cancer. Expand
The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer.
TLDR
A component fish oil, perhaps EPA, merits further investigation in the treatment of cancer cachexia, and changes in weight were accompanied by a temporary but significant reduction in acute phase protein production and by stabilisation of resting energy expenditure. Expand
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TLDR
FO, MLT, or their combination did not induce major biochemical changes indicative of a strong anticachectic effect, Nonetheless, the interventions used may have produced a weight-stabilizing effect. Expand
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TLDR
No significant differences in symptomatic or nutritional parameters were found, and there was no correlation between changes in different variables between days 1 and 14 and the fish oil group. Expand
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The maximum tolerated dose found is considerably higher than anticipated and the observation of a modification of the lipids of leukemic cells, serum, and blood in a patient with chronic leukemia provides a biochemical basis for a possible effect of fish oil supplements on cancer cachexia and tumor growth. Expand
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The treatment has been shown to be effective for clinical response, increase of lean body mass, decrease of reactive oxygen species and proinflammatory cytokines, and improvement of quality of life. Expand
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TLDR
Compliance with the prescription of 1.5 cans of a protein and energy dense, oral nutrition supplement +/-n-3 fatty acids improved nutrition related outcomes in untreated pancreatic cancer patients. Expand
Nutrition intervention using an eicosapentaenoic acid (EPA)-containing supplement in patients with advanced colorectal cancer. Effects on nutritional and inflammatory status: a phase II trial
TLDR
Dietary counseling and the provision of EPA-ONS may result in maintenance of nutritional status and QOL, however randomized trials are required to evaluate the impact of EPA on toxicity from chemotherapy. Expand
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