A systematic review of viral infections associated with oral involvement in cancer patients: a spotlight on Herpesviridea

  title={A systematic review of viral infections associated with oral involvement in cancer patients: a spotlight on Herpesviridea},
  author={Sharon Elad and Yehuda Zadik and Ian Hewson and Allan J Hovan and Maria Elvira Pizzigatti Corr{\^e}a and Richard M Logan and Linda S. Elting and Fred K. L. Spijkervet and Michael T. Brennan and Oral Care Study Group Multinational Association of Supp Viral Infections Section},
  journal={Supportive Care in Cancer},
PurposeOur aim was to evaluate the literature for the prevalence of and interventions for oral viral infections and, based on scientific evidence, point to effective treatment protocols. Quality of life (QOL) and economic impact were assessed if available in the articles reviewed.MethodsOur search of the English literature focused on oral viral infections in cancer patients within the timeframe of 1989–2007. Review methods were standardized. Cohort studies were used to determine the weighted… 
A systematic review of oral herpetic viral infections in cancer patients: commonly used outcome measures and interventions
Acyclovir and valacyclovir are effective in the management of oral herpetic infections in patients receiving treatment for cancer and studies on newer anti-viral drugs may be useful to address the issue of anti-Viral resistance.
Investigation of the oral infections and manifestations seen in patients with advanced cancer
Oral infection is prevalent among advanced cancer patients and associated with therapy methods and risk factors, and more oral health care should be carried out for the patients with advanced malignant tumor.
Prospective evaluation of HSV, Candida spp., and oral bacteria on the severity of oral mucositis in pediatric acute lymphoblastic leukemia
BackgroundOral mucositis is a common collateral effect among the secondary complications resulting from chemotherapy. The objective of this study was to prospectively evaluate the association of
Seroprevalence of herpes virus associated with the presence and severity of oral mucositis in children diagnosed with acute lymphoid leukemia.
It was possible to conclude that infection by the herpes viruses HSV-1, EBV, and CMV is ubiquitous in the studied population and that HSv-1 may be a risk factor for aggravating the severity of mucositis.
Seroprevalence of HSV-1/2 and correlation with aggravation of oral mucositis in patients with squamous cell carcinoma of the head and neck region submitted to antineoplastic treatment
The reactivation of HSV-1/2 was shown to be relatively infrequent and there was no correlation between presence of the virus and aggravation of oral mucositis resulting from antineoplastic treatment.
There was no statistically significant correlation between the presence of EBV, CMV, HSV-1 and G and epidemiological features such as place of residence and T and alcohol use.
Herpesvirus in the oral cavity of children with leukaemia and its impact on the oral bacterial community profile
The prevalence of herpesviruses and the qualitative bacterial profiles was higher in children with leukaemia and HCMV,HHV-7 and HHV-8 were related to the use of chemotherapy.
HSV-1 as well as HSV-2 is frequent in oral mucosal lesions of children on chemotherapy
In a novel finding, real-time PCR detected copies of HSV-2 in 69 % cases, all missed by conventional PCR, which is commonly shed from oral mucosal lesions in children receiving chemotherapy.
TNF as marker of oral candidiasis, HSV infection, and mucositis onset during chemotherapy in leukemia patients.
AL patients undergoing chemotherapy with high salivary TNF levels were more likely to develop HSV infection, OC, and OM.
Viral loads and antiviral resistance of herpesviruses and oral ulcerations in hematopoietic stem cell transplant recipients
HSV-1 is a predictor of ulcerations on non-keratinized as well as keratinized oral mucosa following HSCT, and the role of EBV deserves further study.


The incidence of oral herpes simplex virus infection in patients undergoing cancer chemotherapy.
Oral-disease prevention in children with cancer: testing preventive protocol effectiveness.
Of the oral complications evaluated, gingivitis registered the highest percentage, followed by mucositis (18%) and candida albicans infection (7%).
Oral ulcers in children under chemotherapy: clinical characteristics and their relation with Herpes Simplex Virus type 1 and Candida albicans.
Oral ulcers in children with oncological diseases did not present a specific clinical pattern, and they were strongly associated with HSV.
Herpes simplex virus detection in oral mucosa lesions in patients undergoing oncologic therapy.
It is very important to corroborate clinical diagnosis of gingivitis and ulcerative lesions of the oral cavity of patients under oncologic therapy with laboratory tests, because of the atypical clinical presentation that can lead to misdiagnosis.
Herpes simplex virus-1 (HSV-1) infection in radiation-induced oral mucositis
Healing or reduction in the grade of mucositis after antivirals in HSV-1 positive patients, combined with the negative response to antiviral treatment in HSv-1 negative patients, denoted that HSV -1 infection was a component of ulcerative radiation mucositi in those HSV.1-positive patients.
Acyclovir given as prophylaxis against oral ulcers in acute myeloid leukaemia: randomised, double blind, placebo controlled trial
Intraoral ulcers excluding the hard palate are most often due to infection with herpes simplex virus, whereas ulcers on the soft palate have a non-herpetic aetiology.
Herpes simplex virus and oral mucositis in children with cancer
The results suggest that oral mucositis in children receiving antineoplastic treatment is probably multifactorial in origin and that HSV can be an important cofactor, especially in children who are seropositive for HSV.
Antiviral prophylaxis with continuous low dose acyclovir in childhood cancer
Prophylactic acyclovir has beenadministered in the authors' department to all patients with leukemia or solid tumor receiving chemotherapy, along with trimethoprim-sulphomethoxazole and no pediatric cancer centers give acylovir for viral prophylaxis, other than BMT.
Prevention and management of oral infections in cancer patients
  • A. Heimdahl
  • Medicine, Biology
    Supportive Care in Cancer
  • 1999
Abstract The successful prevention and management of oral infections and infections from the oral cavity in cancer patients are based on identification of risk patients, selection of patients for