A systematic review of the pharmacokinetic and pharmacodynamic interactions of herbal medicine with warfarin

@article{Choi2017ASR,
  title={A systematic review of the pharmacokinetic and pharmacodynamic interactions of herbal medicine with warfarin},
  author={Songie Choi and Dal-Seok Oh and Ui Min Jerng},
  journal={PLoS ONE},
  year={2017},
  volume={12}
}
Objectives The aim of this study was to systematically review data regarding pharmacokinetic (PK)-pharmacodynamic (PD) parameters from randomized controlled trials relating to interactions between herbal medicines and warfarin. Methods Three electronic databases were searched to identify relevant trials. Two reviewers independently performed the study selection and data extraction. The risk of bias and reporting quality were also assessed independently by two reviewers using the Cochrane risk… Expand

Paper Mentions

Interaction of herbal products with prescribed medications: A systematic review and meta‐analysis
TLDR
The study findings suggest that GT, SJW and EP perpetuate significant interactions with prescribed medications via CYP3A4 or OATP1A2 and show that meta‐analyses are important in the area of natural products to provide necessary information on their use in overall medication plans in order to avoid unintended interactions. Expand
Prevalence of Warfarin Drug Interaction and Warfarin Education Practice in Outpatient Setups of University Teaching Hospital
Introduction: Pharmacokinetic, pharmacodynamic and narrow therapeutic index properties of warfarin makes it particularly susceptible to interactions with a number of prescription and nonprescriptionExpand
Decrease in Efficacy of Warfarin as a Result of Drug-Drug Interaction (Case Report)
TLDR
A case of a decrease in the efficacy of warfarin in a patient with mitral stenosis while taking a combined choleretic drug is presented in the article. Expand
Potential Therapeutic Benefits of Herbs and Supplements in Patients with NAFLD
TLDR
Preliminary data on several herbs have demonstrated promising antioxidant, anti-inflammatory,Anti-apoptotic, and anti-adipogenic properties that may help curtail the progression of NAFLD/NASH. Expand
Pharmacokinetic drug interactions of the non‐vitamin K antagonist oral anticoagulants (NOACs)
TLDR
An overview of NOACs PK profiles and their drug‐drug interactions potential is given to be of help to physicians in choosing the best therapeutic approach for their patients. Expand
Influence of andrographolide on the pharmacokinetics of warfarin in rats
Abstract Context: Andrographolide and warfarin are often used together in clinics in China. However, the herb-drug interaction between andrographolide and warfarin is still unknown. Objective: ThisExpand
A comprehensive quality analysis of randomized controlled clinical trials of Asian ginseng and American ginseng based on the CONSORT guideline
TLDR
It was found that the reporting quality of the two species has improved during the past 40 years, and Rigorous RCTs designed for the species of ginseng are warranted, which can shed light on product research and development of gINSeng in the future. Expand
Panax ginseng for Frailty-Related Disorders: A Review
TLDR
Some evidence is shown for the usefulness of ginseng, which suggests that it has the potential to be used for the management of aging-related and frailty symptoms, such as fatigue and hypertension. Expand
Evaluation of bleeding-related adverse events following acupuncture treatment in patients on anticoagulant or antiplatelet drugs: A prospective observational study.
TLDR
The findings suggest that anticoagulant and antiplatelet drugs do not increase the incidence of bleeding-related adverse events after acupuncture treatment. Expand
Can medicinal properties of watercress be relevant to human health? A systematic review based on preclinical study in vivo
TLDR
This systematic review of preclinical studies with Nasturtium in animals showed positive effects on the improvement of the immune system, hypoglycemic hypercholesterolemia, and anti-inflammatory activity, sex hormones synthesis, the preventive effect on the renal stone formation, and others. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 53 REFERENCES
Investigation of the Effects of Herbal Medicines on Warfarin Response in Healthy Subjects: A Population Pharmacokinetic‐Pharmacodynamic Modeling Approach
TLDR
None of the herbs studied had a direct effect on warfarin pharmacodynamics, and studies in anticoagulated patients are warranted to assess the clinical significance of these herb‐drug interactions. Expand
Recommendations for reporting randomized controlled trials of herbal interventions: Explanation and elaboration.
TLDR
Recommendations for the reporting of herbal medicinal products are developed in which several CONSORT items were elaborated to become relevant and complete for randomized controlled trials of herbal medicines. Expand
Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction.
TLDR
Interaction between herbal medicine and cardiovascular drugs is a potentially important safety issue and patients taking anticoagulants are at the highest risk. Expand
Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects.
TLDR
Ginkgo and ginger at recommended doses do not significantly affect clotting status, the pharmacokinetics or pharmacodynamics of warfarin in healthy subjects and these herbs did not affect CYP2C9 activity. Expand
Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects.
TLDR
Echinacea significantly reduced plasma concentrations of S-warfarin, however, neither echinacea nor policosanol significantly affected warfarin pharmacodynamics, platelet aggregation or baseline clotting status in healthy subjects. Expand
Interactions of Warfarin with Garlic, Ginger, Ginkgo, or Ginseng: Nature of the Evidence
TLDR
The true risks of these interactions and effects are difficult to characterize due to the limited number and nature of existing reports. Expand
Aged garlic extract may be safe for patients on warfarin therapy.
TLDR
The results suggest that AGE is relatively safe and poses no serious hemorrhagic risk for closely monitored patients on warfarin oral anticoagulation therapy and its positive effects may be beneficial to people with a high-risk background or who are taking cardiovascular medications. Expand
Updates on the Clinical Evidenced Herb-Warfarin Interactions
TLDR
In summary, herb-warfarin interaction, especially the clinical effects of herbs on warfarin therapy should be further investigated through multicenter studies with larger sample sizes. Expand
Reporting Randomized, Controlled Trials of Herbal Interventions: An Elaborated CONSORT Statement
TLDR
This study elaborated on the 22-item checklist of the Consolidated Standards of Reporting Trials (CONSORT) statement to help authors and editors improve reporting of RCTs of herbal interventions and emphasized minimizing item elaborations and additions and basing elaborations on evidence whenever possible. Expand
An Overview of the Evidence and Mechanisms of Herb–Drug Interactions
TLDR
The potential for HDI should always be assessed in the non-clinical safety assessment phase of drug development process and an increased level of awareness of HDI is necessary among health professionals and drug discovery scientists. Expand
...
1
2
3
4
5
...