A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs

  title={A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs},
  author={Yiyi Sun and Keli Xun and Yitao Wang and Xiuping Chen},
  journal={Anti-Cancer Drugs},
Natural products represent a rich reservoir of potential small chemical molecules exhibiting antiproliferation and anticancer properties. An example is berberine, a protoberberine alkaloid widely distributed in medical plants used in traditional Chinese prescriptions. Recent advances have shown that berberine exerts anticancer activities both in vitro and in vivo through different mechanisms. Berberine shows inhibitory effects on the proliferation and reproduction of certain tumorigenic… 

Anticancer Potential of Natural Isoquinoline Alkaloid Berberine

Though berberine is a relatively safe compound, it should not be prescribed to pregnant or lactating women to avoid adverse effects on developing fetuses and neonates.

Emerging Alkaloids Against Cancer: A Peep into Factors, Regulation, and Molecular Mechanisms

  • P. KatyalShivani Sharma
  • Biology, Chemistry
    Bioactive Natural Products for the Management of Cancer: from Bench to Bedside
  • 2019
Alkaloids play a crucial role in regulating cell cycle by increasing cancerous cell death, angiogenesis, autophagy, alteration of mitochondrial membrane, and COX-2, Bcl-2 and BCl-XL regulation for inducing caspase activity.

Several Alkaloids Derived from Plants and Their Underlying Molecular Mechanisms of Action in the Fight Against Cancer

Alkaloids show remarkable potential as anticancer agents, however, more research and clinical trials are crucial before applying any of these alkaloids as new medicine to treat cancer patients.

The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review

A systematic summary of the anticancer profile and the underlying mechanisms of the bioactive compounds isolated from Danshen with special emphasis on tanshinones is provided, aiming to bring new insights for further research and development of this ancient herb.

Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system

The advances in studing berberine and its derivatives as anti-inflammatory and anti-tumor agents in the digestive system are summarized and their structure-activity relationship is discussed.

Berberine: a potential phytochemical with multispectrum therapeutic activities

A relatively large number of studies discussed here have revealed the possible areas where this phytochemical constituent can exhibit its therapeutic activities in the treatment of chronic ailments or diseases including diabetes, cancer, depression, hypertension and hypercholesterolemia.

Synthesis and Anticancer Activity of Novel 9-O-Substituted Berberine Derivatives

Berberine is a bioactive isoquinoline alkaloid derived from many plants. Although berberine has been shown to inhibit growth and induce apoptosis of several tumor cell lines, its poor absorption and

In vitro and in vivo antitumor efficacy of berberine-nanostructured lipid carriers against H22 tumor

Ber loaded nanostructured lipid carriers (Ber-NLC) was prepared by hot melting and then high pressure homogenization technique and results suggest that the delivery of Ber-N LC is a promising approach for treating tumors.



Berberine induces apoptosis through a mitochondria/caspases pathway in human hepatoma cells

It is demonstrated that berberine exhibited significant cytotoxicity in hepatoma HepG2 cells but is ineffective in Chang liver cells, and the potential of anti-hepatoma activity of berberines may be mediated through a caspases-mitochondria-dependent pathway.

Berberine modulates expression of mdr1 gene product and the responses of digestive track cancer cells to Paclitaxel

Berberine modulated the expression and function of pgp-170 that leads to reduced response to Paclitaxel in digestive track cancer cells, which is suggested to be a major constituent of Coptis chinese.

Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway.

The cytostatic/cytotoxic effects of berberine do not seem to result from inhibition of the mevalonate pathway.

Berberine induces G1 arrest and apoptosis in human glioblastoma T98G cells through mitochondrial/caspases pathway.

Results demonstrate that the berberine-induced apoptosis of T98G cells is primarily mediated through the mitochondrial/caspases-dependent pathway.

Berberine induced down-regulation of matrix metalloproteinase-1, -2 and -9 in human gastric cancer cells (SNU-5) in vitro.

Berberine, a yellow benzylisoquinoline alkaloid, is a constituent of Coptis chines and is commonly used in Chinese herbal medicine for patients with gastrointestinal disorders. The pharmacological