A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs

@article{Sun2009ASR,
  title={A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs},
  author={Yiyi Sun and Keli Xun and Yitao Wang and Xiuping Chen},
  journal={Anti-Cancer Drugs},
  year={2009},
  volume={20},
  pages={757-769}
}
Natural products represent a rich reservoir of potential small chemical molecules exhibiting antiproliferation and anticancer properties. An example is berberine, a protoberberine alkaloid widely distributed in medical plants used in traditional Chinese prescriptions. Recent advances have shown that berberine exerts anticancer activities both in vitro and in vivo through different mechanisms. Berberine shows inhibitory effects on the proliferation and reproduction of certain tumorigenic… 

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It is demonstrated that berberine exhibited significant cytotoxicity in hepatoma HepG2 cells but is ineffective in Chang liver cells, and the potential of anti-hepatoma activity of berberines may be mediated through a caspases-mitochondria-dependent pathway.

Berberine modulates expression of mdr1 gene product and the responses of digestive track cancer cells to Paclitaxel

Berberine modulated the expression and function of pgp-170 that leads to reduced response to Paclitaxel in digestive track cancer cells, which is suggested to be a major constituent of Coptis chinese.

Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway.

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Berberine, a yellow benzylisoquinoline alkaloid, is a constituent of Coptis chines and is commonly used in Chinese herbal medicine for patients with gastrointestinal disorders. The pharmacological
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