A systematic review of seizure clusters: Prevalence, risk factors, burden of disease and treatment patterns

  title={A systematic review of seizure clusters: Prevalence, risk factors, burden of disease and treatment patterns},
  author={Steve S. Chung and Jerzy P. Szaflarski and Eun Jung Choi and Jessica Claire Wilson and Saifuddin Kharawala and Gavneet Kaur and Lawrence J. Hirsch},
  journal={Epilepsy Research},

Updated review of rescue treatments for seizure clusters and prolonged seizures

Clinical opportunities for rescue medications, with particular attention focused on seizure clusters and prolonged seizures, are discussed, including their epidemiology, risk factors, and associated morbidity.

Forecasting seizure clusters from chronic ambulatory electrocorticography

The feasibility study demonstrates that seizure clusters are quasiperiodic and can be forecasted to clinically meaningful horizons and may herald chronotherapy during imminent heightened seizure vulnerability.

Sleep Disturbances in Chinese Children with Epilepsy: Associations with Behavioral Problems and Quality of Life

Sleep disturbances occur frequently among Chinese children with epilepsy, and are associated with more behavioral problems and lower QOL, suggesting the sleep disturbance-QOL association is unlikely contingent on behavioral problems.

NSS_A_367900 1225..1236

  • 2022



Seizure clusters: characteristics and treatment.

  • S. Haut
  • Medicine
    Current opinion in neurology
  • 2015
Progress towards the development of nonintravenous routes of benzodiazepines has the potential to improve care in this area and greater focus on clarifying of definition and clinical implications is required.

Seizure clustering during drug treatment affects seizure outcome and mortality of childhood-onset epilepsy.

Cl clustering of seizures during treatment, but not prior to treatment, is associated with a poorer long-term seizure and mortality outcome, and patients with seizure clustering prior to, butNot during, treatment versus those with no clustering showed no difference in seizure outcome or mortality risk.

Seizure clusters in drug‐resistant focal epilepsy

It is found that seizure clusters relate to prognosis after temporal lobe surgery in drug‐resistant TLE and may provide added value for surgical prognostication when combined with other data types.

Burden of Seizure Clusters on Patients with Epilepsy and Caregivers (P6.343)

The burden of SC on patient and caregiver quality of life includes emotional, financial, and social components and suggest the need for increased education on managing SC and improved rescue therapies to potentially reduce burden of illness.

Course of chronic focal epilepsy resistant to anticonvulsant treatment

There is no evidence for a unique type of course in chronic focal epilepsy in patients on antiepileptic drugs, and the variance of the daily seizure frequency was in most patients significantly higher or lower than corresponding random distributions.