A systematic review of oral methotrexate for multiple sclerosis

@article{Gray2006ASR,
  title={A systematic review of oral methotrexate for multiple sclerosis},
  author={O. Gray and G. McDonnell and R. Forbes},
  journal={Multiple Sclerosis},
  year={2006},
  volume={12},
  pages={507 - 510}
}
Oral methotrexate is a potent immunosuppressant, which could have a beneficial effect on relapse rates and delay disease progression in multiple sclerosis (MS). We performed a systematic review of all randomized controlled trials of oral methotrexate for MS. Of the two randomized controlled trials identified, one was excluded due to its allocation concealment and definition of a relapse and time to sustained disease progression. The other trial studied 60 participants with progressive MS only… Expand
Progressive Multiple Sclerosis
TLDR
None of the therapies currently approved for use in relapsing-remitting MS have been shown to slow the gradual progression of disability that occurs in the absence of recent relapses or changes in MRI. Expand
High‐Dose Cyclophosphamide in the Treatment of Multiple Sclerosis
TLDR
Results along with previous reports suggest that early use of HDC therapy in RRMS is promising, and HDC was well tolerated, demonstrated a good safety profile and had minimal adverse effects. Expand
Immunosuppressive treatments in multiple sclerosis.
  • D. Okuda
  • Medicine
  • Handbook of clinical neurology
  • 2014
TLDR
This chapter focuses on the most widely used immunosuppressive treatments in MS: cyclophosphamide, methotrexate, azathioprine, mycophenolate mofetil, and the only FDA-approved chemotherapeutic agent for the treatment of MS, mitoxandrone. Expand
Chemotherapeutics in the treatment of multiple sclerosis
TLDR
The likely pathogenic mechanisms of multiple sclerosis provide a sound rationale for investigating the efficacy of drugs possessing immunosuppressive or immunomodulatory properties, and a thorough risk-benefit analysis is becoming increasingly important in the assessment of therapeutic options for this disabling disease. Expand
Latin American algorithm for treatment of relapsing-remitting multiple sclerosis using disease-modifying agents.
TLDR
The present paper translated an effort from representatives of eight countries discussing a matter that cannot be adapted to the authors' region directly from purely European and North-American guidelines for treatment. Expand
Therapeutic Approaches to Multiple Sclerosis
TLDR
This review summarizes trials on MS treatments since 2001 that failed or were interrupted, attempts to analyze the underlying reasons for failure, and discusses the implications for the current view of MS pathogenesis, clinical practice, and design of future studies. Expand
Immunotherapy of Multiple Sclerosis
TLDR
This review summarizes in detail the existing information on all the available immunotherapies for MS, classifies them according to their immunologic mechanisms of action and proposes a structured algorithm/therapeutic scheme for the management of the disease. Expand
A narrative review of psoriasis and multiple sclerosis: links and risks
TLDR
It is concluded that further study is necessary to discern whether there may be a significant relationship between PsO and MS, and clinicians may find it appropriate to screen for MS in patients with PsO, allowing for timely referral to a neurologist should it be necessary. Expand
Management of multiple sclerosis in adolescents – current treatment options and related adherence issues
Multiple sclerosis (MS) is a progressive inflammatory demyelinating disorder of the central nervous system that is increasingly recognized in children and adolescents. This realization comes withExpand
Neurotherapeutic Strategies for Multiple Sclerosis.
TLDR
approved FDA therapies as well as commonly used practice-based therapies for MS, aswell as those therapies that can be used in patients attempting to become pregnant, or in patients with an established pregnancy, who require concomitant treatment secondary to recalcitrant disease activity are discussed. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 13 REFERENCES
Methotrexate for multiple sclerosis.
BACKGROUND Methotrexate is a potent immunosuppressant which in theory could reduce relapse rates and delay disease progression in multiple sclerosis (MS). Subsequently, clinical trials ofExpand
Low‐dose (7.5 mg) oral methotrexate reduces the rate of progression in chronic progressive multiple sclerosis
TLDR
It is concluded that low‐dose, weekly, oral methotrexate offers a new, relatively nontoxic treatment option for patients with chronic progressive MS. Expand
Methotrexate hepatotoxicity: What is the evidence?
TLDR
MTX has become the most commonly prescribed anti-rheumatic drug used in the treatment of RA and is well tolerated in the long term: data show that approximately 50% of patients are still taking MTX after 5 years of treatment. Expand
Methotrexate: mechanism of action in rheumatoid arthritis.
TLDR
MTX effects in RA are not fully understood and further studies are needed to clarify its mechanism of action, which might be more antiinflammatory than immunosuppressive. Expand
Low dose oral methotrexate treatment of multiple sclerosis: a pilot study.
An 18-month double-blind treatment of multiple sclerosis with low dose oral methotrexate showed it to be well tolerated and suggested effectiveness in exacerbating-remitting MS but not in theExpand
The initiation of the autoimmune response in multiple sclerosis
TLDR
Insight is provided into the physiologic and pathologic role of autoreactive T-cells, and structurally and functionally the specific targets for new therapies of MS are characterized. Expand
New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
TLDR
Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS. Expand
Acute and chronic suppression of leukotriene B4 synthesis ex vivo in neutrophils from patients with rheumatoid arthritis beginning treatment with methotrexate.
TLDR
It is concluded that weekly oral MTX therapy in patients with active rheumatoid arthritis inhibits neutrophil 5-LO pathway product generation in a pattern consistent with inhibition of the activity of the 5- LO enzyme; an effect is observed after the first dose. Expand
Possible role of histamine in pathogenesis of autoimmune diseases: implications for immunotherapy with histamine-2 receptor antagonists.
TLDR
The finding that CsA and Mx efficiently reduce histamine formation and release raises the possibility, that histamine is one of the molecules involved in pathogenesis of autoimmune diseases. Expand
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.
TLDR
Results indicate that methotrexate is a nonsteroidal antiinflammatory agent, the antiphlogistic action of which is due to increased adenosine release at inflamed sites. Expand
...
1
2
...