A systematic review of modafinil: Potential clinical uses and mechanisms of action.

@article{Ballon2006ASR,
  title={A systematic review of modafinil: Potential clinical uses and mechanisms of action.},
  author={J. Ballon and D. Feifel},
  journal={The Journal of clinical psychiatry},
  year={2006},
  volume={67 4},
  pages={
          554-66
        }
}
BACKGROUND Modafinil is a novel wake-promoting agent that has U.S. Food and Drug Administration approval for narcolepsy and shift work sleep disorder and as adjunctive treatment of obstructive sleep apnea/hypopnea syndrome. Modafinil has a novel mechanism and is theorized to work in a localized manner, utilizing hypocretin, histamine, epinephrine, gamma-aminobutyric acid, and glutamate. It is a well-tolerated medication with low propensity for abuse and is frequently used for off-label… Expand
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