A systematic review of maternal and infant outcomes following magnesium sulfate for pre‐eclampsia/eclampsia in real‐world use

@article{McDonald2012ASR,
  title={A systematic review of maternal and infant outcomes following magnesium sulfate for pre‐eclampsia/eclampsia in real‐world use},
  author={Sarah Diana McDonald and Olha Lutsiv and Nancy Dzaja and Lelia Duley},
  journal={International Journal of Gynecology \& Obstetrics},
  year={2012},
  volume={118}
}
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59 Citations
Background Citations
25
Results Citations
2

59 Citations

Citation Type

Citation Type

Impact of pre‐eclampsia in extremely premature infants: Population‐based study
TLDR
This study investigated neonatal mortality and morbidity of maternal pre‐eclampsia and clinical CAM in extremely premature infants using data from a population‐based cohort study.
Reducing maternal mortality from preeclampsia and eclampsia in low‐resource countries – what should work?
TLDR
This work evaluated interventions to reduce PE/E‐related maternal mortality in sub‐Saharan Africa and found that maternal death in low‐income countries is higher than the global average due to PE/eclampsia.
Eclampsia in Finland; 2006 to 2010
TLDR
The aim of this study was to assess the incidence of eclampsia in Finland after the increased use of magnesium sulfate in the late 1990s.
An integrative review of the side effects related to the use of magnesium sulfate for pre-eclampsia and eclampsia management
TLDR
Concerns about safety and toxicity from the use of magnesium sulfate should be mitigated by findings from this integrative review, which indicates a low incidence of the most severe side effects, documented in studies that used a wide variety of standard and modified drug regimens.
Prophylactic magnesium sulphate in prevention of eclampsia in women with severe preeclampsia: randomised controlled trial (PIPES trial)
TLDR
It is shown that short regime of magnesium sulphate using only the loading dose in the prevention of seizure in preeclampsia is an effective alternative to the low-dose Dhaka regime.
Magnesium sulphate therapy in eclampsia and pre-eclampsia
TLDR
Magnesium sulphate regimen was effective in control of convulsions in eclampsia and as prophylaxis in imminent eClampsia.
Shortened postpartum magnesium sulfate treatment vs traditional 24h for severe preeclampsia: a systematic review and meta-analysis of randomized trials
TLDR
Shortened postpartum magnesium sulfate treatment was as effective as traditional 24 h magnesium sulfates in seizure prevention and total complications and warrants further research.
Attrition from care after the critical phase of severe pre-eclampsia and eclampsia: Insights from an intervention with magnesium sulphate in a primary care setting in northern Nigeria
TLDR
This study suggests that lower-cadre health care professionals at PHCs can administer the loading dose of MgSo4 to SPE/E patients to improve maternal and fetal survival in critical states, without significant risk of adverse effects.
ROLE OF MAGNESIUM SULPHATE IS AN EFFECTIVE THERAPY FOR THE TREATMENT AND PROPHYLAXIS OF SEIZURES IN PRE ECLAMPSIA AND ECLAMPSIA
TLDR
The management of eclampsia aimed to stop convulsion and prevent recurrence, control of blood pressure and deliver the patient promptly.
Treatment with Magnesium in Pregnancy
TLDR
The aims of the review is to describe the major studies performed on treatment with magnesium in pregnancy related complications and the studies reviewed were collected from a previous Cochrane review.
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References

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Reducing maternal mortality from eclampsia, using magnesium sulphate.
Outcomes of severe pre‐eclampsia/eclampsia in Yorkshire 1999/2003
TLDR
To establish the risk of serious complications from severe pre‐eclampsia and eClampsia in a region using a common guideline for the management of these conditions, a large number of patients with these conditions are admitted to hospital.
Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial
Eclampsia in the United Kingdom 2005
TLDR
The national incidence of eclampsia in the UK and the management and associated outcomes since the introduction of magnesium sulphate are estimated.
Management of eclampsia at AKTH: before and after magnesium sulphate.
  • J. Tukur, Z. Muhammad
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TLDR
This study is in support of the findings that magnesium sulphate is superior to diazepam in the reduction of maternal morbidity and mortality.
Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial
Magnesium sulphate and other anticonvulsants for women with pre-eclampsia.
TLDR
Magnesium sulphate more than halves the risk of eclampsia, and probably reduces therisk of maternal death, and does not improve outcome for the baby, in the short term.
Magnesium sulphate versus phenytoin for eclampsia.
TLDR
Magnesium sulphate appears to be substantially more effective than phenytoin for treatment of eclampsia, with a substantial reduction in the recurrence of convulsions.
Magnesium sulphate versus diazepam for eclampsia.
TLDR
Magnesium sulphate appears to be substantially more effective than diazepam for treatment of eclampsia.
Comparison of Lytic Cocktail and Magnesium Sulphate Regimens in Eclampsia: A Retrospective Analysis
TLDR
Retrospective analysis of eclamptic patients was done and incidence of persistent convulsions was significantly lower with magnesium sulphate compared to lytic cocktail and perinatal mortality was similar in both groups.
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