A systematic review of longitudinal outcome studies of first-episode psychosis

  title={A systematic review of longitudinal outcome studies of first-episode psychosis},
  author={Natasja M. Menezes and Tamara Arenovich and Robert B Zipursky},
  journal={Psychological Medicine},
  pages={1349 - 1362}
Background. Existing outcome literature has had an over-representation of chronic patients and suggested a progressive course and poor outcome for schizophrenia. The current study aimed to recombine data of samples from longitudinal studies of first-episode psychosis (FEP) to describe outcome and its predictors. Method. A literature search (1966–2003) was conducted for prospective studies examining outcome in first-episode non-affective psychosis using the following key words: early, first… 
Predictors of outcome in the early course of first-episode psychosis
Residual symptoms appear to be an especially useful index of clinical and functional status for examining the course and outcome of first-episode psychosis.
Reappraising the long-term course and outcome of psychotic disorders: the AESOP-10 study
Sustained periods of symptom remission are usual following first presentation to mental health services for psychosis, including for those with a non-affective disorder; almost half recover.
Predictors of outcome in first-episode schizophrenia over the first 4 years of illness
The outcome of schizophrenia may not be as pessimistic as once thought and most patients did not display a downward deteriorating course of illness and the relationship between DUP and outcome beyond the early stages of illness is supported.
Proportion and predictors of remission and recovery in first-episode psychosis: Systematic review and meta-analysis
Half of the patients are in symptomatic remission around 4 years after the FEP, while about a third show recovery after 5 years, and no significant effect of any sociodemographic or clinical predictor was found.
Predictors of Remission and Recovery in a First-Episode Schizophrenia Spectrum Disorder Sample: 2-Year Follow-up of the OPUS Trial
Predictors of good outcome for patients with first-episode schizophrenia spectrum disorder should be focused on potentially malleable predictors of outcome, for example, reducing DUP and paying special attention to patients who are unlikely to achieve good outcome.
Dissecting the functional outcomes of first episode schizophrenia spectrum disorders: a 10-year follow-up study in the PAFIP cohort
It is demonstrated that distinct clusters of functioning in FEP patients can be identified and has clinical implications for developing individualized treatment plans.
First episode psychosis and outcome : Findings from a swedish multi-centre study
The results showed that it is possible to provide “need-adapted care” to persons suffering from psychosis, but further studies with a naturalistic design are needed to increase knowledge regarding what ingredients are effective and how various interventions interact.
Cognitive markers of short-term clinical outcome in first-episode psychosis
The early identification of those individuals with first-episode psychosis with a poor clinical outcome may encourage clinicians to pay special attention to them in the form of alternative pharmacological and psychological treatments for a more favourable outcome in the long term.


The Varied Outcomes of Schizophrenia
The early appearance and stability over time of negative symptoms and cognitive impairments call for assertive intervention efforts early in the course of disorder to prevent chronicity and prolonged disability.
Prediction of Outcome Following a First Episode of Schizophrenia
The findings challenge the conventional view that symptoms of depression are associated with better outcome in schizophrenia and suggest that depressive delusions and higher educational attainment protected against early relapse.
Duration of psychosis and outcome in first-episode schizophrenia.
Duration of psychosis before treatment may be an important predictor of outcome in first-episode schizophrenia, and is significantly associated with time to remission as well as with level of remission.
Recovery from psychotic illness: A 15- and 25-year international follow-up study
A significant proportion of treated incident cases of schizophrenia achieve favourable long-term outcome, and Sociocultural conditions appear to modify long- term course.
The natural course of schizophrenia: a review of first-admission studies.
Methodological improvements in first-admission research are suggested, including separating the analyses of first-episode patients from those with past psychotic experiences, employing longitudinal methods for deriving diagnosis, and enlarging the samples either by multisite or multicenter collaborations or by pooling data across studies.
Outcome of first-episode schizophrenia and the new antipsychotics. A literature review.
  • R. Emsley
  • Psychology
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
  • 1996
This article reviews the English literature over the past 10 years with regard to treatment outcome in first-episode schizophrenia. Particular attention is paid to factors associated w~h poor outcome
Outcome study of first-episode psychosis. I: Relapse rates after 1 year.
One-year relapse rates were assessed in a group of 64 patients diagnosed by Research Diagnostic Criteria who were hospitalized for their first psychotic episode and factors associated with relapse or poor outcome included no maintenance medication, longer duration of illness, and premorbid asociality.
One hundred years of schizophrenia: a meta-analysis of the outcome literature.
Overall, less than half of patients diagnosed with schizophrenia have shown substantial clinical improvement after follow-up averaging nearly 6 years, despite considerable gains in improvement rates after mid-century, there has been a decline since the 1970s.