A systematic review of limited sampling strategies for platinum agents used in cancer chemotherapy.

@article{Loh2007ASR,
  title={A systematic review of limited sampling strategies for platinum agents used in cancer chemotherapy.},
  author={Gabriel W Loh and Lillian S L Ting and Mary H. H. Ensom},
  journal={Clinical pharmacokinetics},
  year={2007},
  volume={46 6},
  pages={471-94}
}
Despite evidence in the literature suggesting that a strong correlation exists between the pharmacokinetic parameters and pharmacodynamic effect of anticancer agents, many of these agents are still dosed by body surface area. Therapeutic drug monitoring with the aim of pharmacokinetic-guided dosing would not only maintain target concentrations associated with efficacy but may potentially minimise the likelihood of dose-related systemic toxicities. The pharmacokinetic parameter that displays the… CONTINUE READING