A systematic review of genetic polymorphisms and breast cancer risk.

  title={A systematic review of genetic polymorphisms and breast cancer risk.},
  author={Alison M. Dunning and Catherine S. Healey and Paul P. D. Pharoah and M Dawn Teare and Bruce A. J. Ponder and Douglas F. Easton},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={8 10},
Studies investigating the relationship between common genetic variants and cancer risk are being reported with rapidly increasing frequency. We have identified 46 published case-control studies that have examined the effect of common alleles of 18 different genes on breast cancer risk. Of these, 12 report statistically significant associations, none of which were reported by more than one study. However, many of the studies were small: 10 of the 46 had 80% power or greater to detect a rare… CONTINUE READING
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