A systematic review of animal models used to study nerve regeneration in tissue-engineered scaffolds.

@article{Angius2012ASR,
  title={A systematic review of animal models used to study nerve regeneration in tissue-engineered scaffolds.},
  author={Diana Angius and Huan Wang and Robert J Spinner and Yearim Gutierrez-Cotto and Michael J. Yaszemski and Anthony J Windebank},
  journal={Biomaterials},
  year={2012},
  volume={33 32},
  pages={8034-9}
}
Research on biomaterial nerve scaffolds has been carried out for 50 years. Only three materials (collagen, polycaprolactone and polyglycollic acid) have progressed to clinical use. Pre-clinical animal models are critical for testing nerve scaffolds prior to implementation in clinical practice. We have conducted a systematic review of 416 reports in which animal models were used for evaluation of nerve regeneration into synthetic conduits. A valid animal model of nerve regeneration requires it… CONTINUE READING

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