A systematic review of Gymnema sylvestre in obesity and diabetes management.

@article{Pothuraju2014ASR,
  title={A systematic review of Gymnema sylvestre in obesity and diabetes management.},
  author={Ramesh Pothuraju and Raj Kumar Sharma and Jayasimha Chagalamarri and Surender Jangra and Praveen Kumar Kavadi},
  journal={Journal of the science of food and agriculture},
  year={2014},
  volume={94 5},
  pages={
          834-40
        }
}
The prevalence of obesity is associated with many health-related problems. Currently, more than 300 million people are considered to be obese. According to the World Health Organization (WHO), by 2030, 87 and 439 million people will be affected in India and the world, respectively. Today, herbal medicines are gaining interest in the treatment of obesity and diabetes, because of their minimal side effects. Gymnemic acid - an active component isolated from Gymnema sylvestre - has anti-obesity and… Expand
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References

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Evaluation of antiobesity and cardioprotective effect of Gymnema sylvestre extract in murine model
TLDR
The significant antiobesity potential of GSE in murine model of obesity has been demonstrated and reversed the effects of high fat diet on cellular obesity and cardiac damage in Wistar rats. Expand
Decreased bodyweight without rebound and regulated lipoprotein metabolism by gymnemate in genetic multifactor syndrome animal
Objective: The aim of this work was to find obesity control method without rebound. In our previous studies, gymnemate extracted from Gymnema sylvestre, inhibited oleic acid absorption. The OtsukaExpand
Antidiabetic plants and their active constituents.
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TLDR
This review provides information on more than 1200 species of plants reported to have been used to treat diabetes and/or investigated for antidiabetic activity, with a detailed review of representative plants and some of great diversity of plant constituents with hypoglycemic activity. Expand
The insulinotropic activity of Gymnema sylvestre, R. Br. An Indian medical herb used in controlling diabetes mellitus.
Summary Gymnema sylvestre, R.Br. a woody climber, growing in unkempt tropical forests of Southern India belonging to the family of Asclepiadaceae has been in use in the treatment of diabetes mellitusExpand
A Novel Extract of Gymnema sylvestre Improves Glucose Tolerance In Vivo and Stimulates Insulin Secretion and Synthesis In Vitro
TLDR
The effects of OSA® are consistent with its potential use as a therapy for the hyperglycemia associated with obesity‐related T2DM. Expand
Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats.
TLDR
Feeding G. sylvestre extract to the diabetic rats decreased the activity of glutathione peroxidase in cytosolic liver and glutamate pyruvate transaminase in serum to normal levels. Expand
Role of selected Indian plants in management of type 2 diabetes: a review.
TLDR
This paper reviews the accumulated literature for 10 Indian herbs that have antidiabetic activity and that have been scientifically tested and proposes Mechanisms such as the stimulating or regenerating effect on beta cells or extrapancreatic effects for the hypoglycemic action of these herbs. Expand
Enzyme changes and glucose utilisation in diabetic rabbits: the effect of Gymnema sylvestre, R.Br.
TLDR
G. sylvestre, a herb used for the control of diabetes mellitus in several parts of India, appears to correct the metabolic derangements in diabetic rabbit liver, kidney and muscle. Expand
A novel Gymnema sylvestre extract stimulates insulin secretion from human islets in vivo and in vitro
Many plant‐based products have been suggested as potential antidiabetic agents, but few have been shown to be effective in treating the symptoms of Type 2 diabetes mellitus (T2DM) in human studies,Expand
The Saponin-Rich Fraction of a Gymnema sylvestre R. Br. Aqueous Leaf Extract Reduces Cafeteria and High-Fat Diet-Induced Obesity
We examined the antiobesity effect of a saponin-rich fraction of a Gymnema sylvestre R. Br. aqueous leaf extract (SGE) using cafeteria and high-fat diet-induced obese rats for a period of eightExpand
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