A systematic review and meta‐analysis of the fertility of patients with schizophrenia and their unaffected relatives

  title={A systematic review and meta‐analysis of the fertility of patients with schizophrenia and their unaffected relatives},
  author={H. Bundy and Dylan S. Stahl and James Hunter MacCabe},
  journal={Acta Psychiatrica Scandinavica},
Bundy H, Stahl D, MacCabe JH. A systematic review and meta‐analysis of the fertility of patients with schizophrenia and their unaffected relatives. 
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More women with schizophrenia are becoming pregnant, such that contemporary data are needed about maternal and newborn outcomes in this potentially vulnerable group. We aimed to quantify maternal and
Pre-morbid fertility in psychosis: Findings from the AESOP first episode study
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It is concluded that gender differences influence the effectiveness of various treatments and need to be taken into account when planning comprehensive care services for individuals with schizophrenia.
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The four cases of N -methyl-D-aspartate (NMDA) receptor antibody encephalitis with associated psychosis reported in December[1][1] raise an important and emerging issue and highlight that
Safety of clozapine use during pregnancy: Analysis of international pharmacovigilance data
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Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs their unaffected siblings.
The results suggest that strong selection exists against schizophrenia, autism, and anorexia nervosa and that these variants may be maintained by new mutations or an as-yet unknown mechanism.
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A complex diagnostic system (Composite Diagnostic Evaluation, CODE) is called attention to which can be a valuable clinical partner of currently accepted models of schizophrenia, such as the neurodevelopmental hypothesis.
General and age-specific fertility rates in non-affective psychosis: population-based analysis of Scottish women
A population-based design combined routinely collected historical maternity and psychiatric data from two representative areas of Scotland to highlight continued low fertility rates in women with a diagnosis of non-affective psychosis, despite widespread availability of prolactin-sparing atypical antipsychotics.


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Evidence is provided against the hypothesis that heterozygous carriers of schizophrenic gene have a reproductive advantage through enhanced fertility and an advantage arising from lower mortality between birth and the end of the reproductive period is investigated.
Differential fertility of adopted schizophrenics and their half‐siblings
This study used several methodological procedures in the study of schizophrenia reproduction, which strengthens the validity of the findings and avoids the biases introduced by using census data or other non‐matched controls.
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Data from the Tomsk Epidemiological Register and epidemiological family sample were used to study the relationship between schizophrenics’ reproductive behaviour, severity of ICD‐9 schizophrenia and risk of illness among relatives of probands.
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The fertility and fecundity of a representative sample of individuals with psychoses who were in contact with mental health services are determined and the interactions between age at first diagnosis and fertility are explored.
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Lower than average fertility among patients with schizophrenia is not compensated for by higher fertility among their siblings, and the persistence of schizophrenia in the general population is not explained by this simple evolutionary mechanism.
Fertility and schizophrenia: evidence for increased fertility in the relatives of schizophrenic patients
Increased fertility in parents and sibs, who are the probable carriers of the abnormal gene, could compensate for the reduction in genetic contribution to morbid risk for schizophrenia due to reduced reproductivity of the patients themselves.
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This review supports the presence of significant differences between schizophrenic males and females arising from the interplay of sex hormones, neurodevelopmental and psychosocial sex differences.
Lifetime reproductive output over two generations in patients with psychosis and their unaffected siblings: the Uppsala 1915–1929 Birth Cohort Multigenerational Study
Schizophrenia, but not affective psychosis, is associated with reduced biological fertility; this disadvantage is partly explained by marital status and persists into the second generation.