A systematic review and economic evaluation of diagnostic strategies for Lynch syndrome.

@article{Snowsill2014ASR,
  title={A systematic review and economic evaluation of diagnostic strategies for Lynch syndrome.},
  author={Tristan Snowsill and Nicola J Huxley and Martin W. Hoyle and Tracey L Jones-Hughes and Helen Coelho and Chris Cooper and Ian M Frayling and Christopher J. Hyde},
  journal={Health technology assessment},
  year={2014},
  volume={18 58},
  pages={1-406}
}
BACKGROUND Lynch syndrome (LS) is an inherited autosomal dominant disorder characterised by an increased risk of colorectal cancer (CRC) and other cancers, and caused by mutations in the deoxyribonucleic acid (DNA) mismatch repair genes. OBJECTIVE To evaluate the accuracy and cost-effectiveness of strategies to identify LS in newly diagnosed early-onset CRC patients (aged < 50 years). Cascade testing of relatives is employed in all strategies for individuals in whom LS is identified. DATA… CONTINUE READING