A systematic investigation of the effect of sample diluent on peak shape in hydrophilic interaction liquid chromatography.

Abstract

The aim of this study was to evaluate the importance of sample diluents to improve peak shapes in hydrophilic interaction liquid chromatography (HILIC), using low molecular weight (<1000 Da) analytes as well as peptides (with MW ranging between 1000 and 6000 Da) as model compounds. Various solvents were tested including water, acetonitrile, methanol… (More)
DOI: 10.1016/j.chroma.2010.10.106

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@article{Ruta2010ASI, title={A systematic investigation of the effect of sample diluent on peak shape in hydrophilic interaction liquid chromatography.}, author={Jos{\'e}phine Ruta and Serge Rudaz and David V. McCalley and J. - L. Veuthey and Davy Guillarme}, journal={Journal of chromatography. A}, year={2010}, volume={1217 52}, pages={8230-40} }