A systematic high-throughput screen of a yeast deletion collection for mutants defective in PHO5 regulation.

  title={A systematic high-throughput screen of a yeast deletion collection for mutants defective in PHO5 regulation.},
  author={Sidong Huang and Erin K O'Shea},
  volume={169 4},
In response to phosphate limitation, Saccharomyces cerevisiae induces transcription of a set of genes important for survival. One of these genes is PHO5, which encodes a secreted acid phosphatase. A phosphate-responsive signal transduction pathway (the PHO pathway) mediates this response through three central components: a cyclin-dependent kinase (CDK), Pho85; a cyclin, Pho80; and a CDK inhibitor (CKI), Pho81. While signaling downstream of the Pho81/Pho80/Pho85 complex to PHO5 expression has… CONTINUE READING
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Global analysis of protein localization in budding cyclinCDK complex

  • Y. Oshima
  • Science
  • 2003

Kakinuma , 1999 Transcription of some PHO genes in Saccharomyces cerevisiae is regulated by spt 7 p Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

  • E. K. O’Shea
  • Nature
  • 2002

Functional analysis of the yeast Glc 7binding protein Reg 1 identition of the ADO 1 gene and study of the mutant phenotypes

  • E. T. Young
  • Mol . Cell . Biol .
  • 1999
1 Excerpt

O ’ Shea tor of gene expression that affects basal expression of pheromonestudy of signaling processes for repression of PHO 5 transcription in Saccharomyces cerevisiae

  • K. E.
  • Genetics Mol . Cell . Biol .
  • 1994

Nucleotide sequence of the PHO 81 gene involved in the visiae gene involved in negative regulation of Gproteinmediated signal transduction

  • J. Vandenhaute
  • EMBO J . Nucleic Acids Res .
  • 1990
1 Excerpt

SNF chromatin remodeling complex

  • E. K. O’Shea, M. Konrad
  • Nat . Struct . Biol .
  • 1988

Isolation and characterizagenome by gene deletion and parallel analysis

  • D. D. Wykoff, E. K. O’Shea
  • J . Bacteriol .
  • 1975

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