A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system.

@article{Zielonka2010ASE,
  title={A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system.},
  author={Matthias Zielonka and Jingjing Xia and Roland H Friedel and Stefan Offermanns and Thomas Worzfeld},
  journal={Experimental cell research},
  year={2010},
  volume={316 15},
  pages={
          2477-86
        }
}
Plexins serve as receptors for semaphorins and play important roles in the developing nervous system. Plexin-B2 controls decisive developmental programs in the neural tube and cerebellum. However, whether Plexin-B2 also regulates biological functions in adult nonneuronal tissues is unknown. Here we show by two methodologically independent approaches that Plexin-B2 is expressed in discrete cell types of several nonneuronal tissues in the adult mouse. In the vasculature, Plexin-B2 is selectively… CONTINUE READING

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