A systematic exploration of the interactions between bacterial effector proteins and host cell membranes

@inproceedings{Weigele2017ASE,
  title={A systematic exploration of the interactions between bacterial effector proteins and host cell membranes},
  author={Bethany Auten Weigele and Robert C Orchard and Alyssa Jimenez and Gregory W. Cox and Neal Mathew Alto},
  booktitle={Nature Communications},
  year={2017}
}
Membrane-bound organelles serve as platforms for the assembly of multi-protein complexes that function as hubs of signal transduction in eukaryotic cells. Microbial pathogens have evolved virulence factors that reprogram these host signaling responses, but the underlying molecular mechanisms are poorly understood. Here we test the ability of ~200 type III and type IV effector proteins from six Gram-negative bacterial species to interact with the eukaryotic plasma membrane and intracellular… CONTINUE READING
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